Back to results
US 2019/0055228 A1Published application
Benzisoxazoles
AssigneeVanda Pharmaceuticals Inc.
InventorsJoachim Nozulak, Hans Kalkman
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel fatty acid esters of the reversible Iloperidone metabolite P-88-8991, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.
Claims12
A compound of Formula I
- wherein R is (C1-40)alkyl or (C1-40)alkenyl, in free base or acid addition salt form, and wherein the acid addition salt form is a pharmaceutically acceptable acid addition salt form.
A method for the production of the compounds of formula I
- wherein R is (C1-40)alkyl or (C1-40)alkenyl, and their salts, the method comprising:
- reacting a compound of formula II
- with a compound of formula III
- wherein R is (C1-40)alkyl or (C1-40)alkenyl and X is halogen;
- and
- recovering the resulting compound in free base or acid addition salt form.
3 more elements
A pharmaceutical composition for the treatment of a psychotic disorder comprising a compound of Formula I,
- wherein R is (C1-40)alkyl or (C1-40)alkenyl, in free base or acid addition salt form;
- and
- a pharmaceutical carrier or diluent.
Dependencies are inferred from the claim text.