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AssigneeMylan Laboratories Limited
InventorsRamakoteswara Rao Jetti, Hemant Malhari Mande, AnJaneyaraju Indukuri, Bommareddy Aggiramireddy, Neelima Bhagavatula, Amit Singh, Soumyajit Ghosh, Attanti Veera Venkata Srinivasarao, Umasankara Sastry Tummalapalli, Veera Venkata Satya Surya Appala Gosula
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The present disclosure provides amorphous lumacaftor, amorphous solid dispersions of lumacaftor, crystalline lumacaftor acetic acid solvate, crystalline lumacaftor ethyl acetate solvate, and processes for the preparation thereof. The lumacaftor forms disclosed herein may be useful for the preparation of oral dosage forms for treating cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases.
Amorphous lumacaftor.
A process for preparing amorphous lumacaftor, comprising the steps of:
-23. (canceled)
A crystalline lumacaftor acetic acid solvate.
A process for the preparation of a crystalline lumacaftor acetic acid solvate comprising the steps of either:
-35. (canceled)
(canceled)
Dependencies are inferred from the claim text.