Histone demethylase inhibitors
AssigneeCelgene Quanticel Research, Inc.
InventorsZhe NIE, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
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Abstract
The present embodiments provide for substituted triazolylpyridine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for modulating the activity of histone demethylase enzymes. Additionally, the subject compounds and compositions are useful for the treatment of cancer or other neoplastic diseases, or maladies associated with abnormal histone demethylase activity. Accordingly, the substituted triazolylpyridine derivative compounds described herein are useful in methods and medicaments for treating cancer.
Claims5
A compound having the structure of Formula II
- wherein a compound of Formula II is optionally a pharmaceutically acceptable salt thereof, and wherein
- R2 is halogen or —CF3;
- R3 is hydrogen, halogen, —OH, —OR6, —N(R6)2, or optionally substituted alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, carbocyclylalkyl, heterocyclylalkyl, aralkyl, or heteroarylalkyl;
- R4 is hydrogen, halogen, —OH, —OR6, —N(R6)2, or optionally substituted alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, carbocyclylalkyl, heterocyclylalkyl, aralkyl, or heteroarylalkyl;
- wherein
- each R6 is independently hydrogen, or optionally substituted alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, carbocyclylalkyl, heterocyclylalkyl, aralkyl, or heteroarylalkyl;
- and
- R5 is hydrogen, methyl, ethyl, isoproplyl, t-butyl, —CHF2, —CH2F, —CF3, —CH2OH, —CHCH3OH, or —C(CH3)2OH.
Dependencies are inferred from the claim text.