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US 2019/0055201 A1Published application
Methods for producing optically active valeric acid derivatives
AssigneeDaiichi Sankyo Company, Limited
InventorsMasaki HAYASHI, Kazutoshi UKAI
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Abstract
A method for producing a compound (4), which comprises allowing a compound (1) to react with hydrogen gas in an inert solvent, in the presence of a specific chiral ligand and a ruthenium catalyst, or in the presence of an asymmetric transition metal complex catalyst previously generated from the chiral ligand and the ruthenium catalyst.
Claims8
A method of producing a compound of formula (5):
- comprising adding (S)-2-amino-1-propanol to a solution comprising the compound of formula (5) to crystallize a salt of formula (7):
- and adding an acid to remove the salt from the compound,
- wherein R1 and R2 are each independently a hydrogen atom or a protective group for the amino group.
A salt of a compound of formula (7):
- wherein R1 and R2 are each independently a hydrogen atom or a protective group for the amino group.
Dependencies are inferred from the claim text.