A process for preparing beta agonist
AssigneeVamsi Labs Ltd.
InventorsG. Pratap REDDY, M. Kesava REDDY
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Abstract
Disclosed is a process for preparing β-agonist, 1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino) ethanol, of Formula I. The process comprises refluxing 1-(4-amino-3,5-dichlorophenyl) ethanone of Formula II and selenium dioxide in the presence of 1,4-dioxane to form compound of Formula III. Further, compound of Formula III is heated at a temperature below 30° C. in the presence of t-butyl amine to form compound of Formula IV. The compound of Formula IV is treated with sodium borohydride to form compound of Formula I.
Claims11
A process for preparing β-agonist, 1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino) ethanol, of Formula I
- comprising the steps of:
- a) refluxing 1-(4-amino-3,5-dichlorophenyl) ethanone of Formula II and selenium dioxide in the presence of 1,4-dioxane to form compound of Formula III;
- b) heating compound of Formula III at a temperature below 30° C. in the presence of t-butyl amine to form compound of Formula IV;
- and
- c) treating compound of Formula IV with sodium borohydride at a predefined temperature to form compound of Formula I.
A process for preparing β-agonist, (1RS)-1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol, of Formula VI
- comprising the steps of:
- a) reacting compound of Formula I with an alcohol in the presence of an activated carbon and tartaric acid at a predefined temperature to form Clenbuterol tartarate salt of Formula V;
- and
- b) treating compound of Formula V with ammonia solution at a predefined temperature and at a predefined pH to form compound of Formula VI.
Dependencies are inferred from the claim text.