Process for the cyclopropanation of olefins using n-methyl-n-nitroso compounds
AssigneeGivaudan SA
InventorsFridtjof SCHRÖDER, Marcel STECK
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Abstract
A process of converting a carbon-carbon double bond on a substrate into a cyclopropane ring, which method comprises the step of treating the substrate with a N-alkyl-N-nitroso compound, a transition metal catalyst and an aqueous base, wherein the N-alkyl-N-nitroso compound is formed by reacting an alkyl amine with an alkali metal nitrite in the presence of a mono-basic or di-basic acid, or a mixture thereof, and wherein the N-alkyl-N-nitroso compound is not distilled before it is mixed with the substrate, catalyst and base.
Claims11
A process of converting a carbon-carbon double bond on a substrate into a cyclopropane ring, the process comprising treating the substrate with a N-alkyl-N-nitroso compound, a transition metal catalyst and an aqueous base, wherein the N-alkyl-N-nitroso compound is formed by reacting an alkyl amine with an alkali metal nitrite in the presence of a mono-basic or di-basic acid comprising a mono-basic or di-basic carboxylic acid, or a mixture thereof, and wherein the N-alkyl-N-nitroso compound is not distilled before it is mixed with the substrate, catalyst and base.
(canceled)
Dependencies are inferred from the claim text.