Neuromodulation device
AssigneesGalvani Bioelectronics Limited, Case Western Reserve University
InventorsAlessandra GIAROLA, Yee-Hsee HSIEH, Stephen J. LEWIS, Arun SRIDHAR
Life of this patent
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Abstract
This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.
Claims20
-69. (canceled)
An apparatus for treating sleep apnoea in a subject, the apparatus comprising:
- i. at least one implantable neural interfacing element having one or more electrodes configured to deliver an electrical signal to at least one cervical sympathetic chain (“CSC”), superior cervical ganglion (SCG) and/or postganglionic branch thereof of the subject and positioned in signalling contact with a left cervical sympathetic chain (“CSC”), superior cervical ganglion (SCG) and/or postganglionic branch thereof or a right cervical sympathetic chain (“CSC”), superior cervical ganglion (SCG) and/or postganglionic branch thereof;
- and
- ii. a controller operably coupled to the neural interfacing element, which controller programs the neural interfacing element to deliver the electrical signal that increases localized sympathetic activity of the CSC, SCG and/or postganglionic branch,
- wherein increased sympathetic activity of the CSC, SCG and/or postganglionic branch ameliorates sleep apnoea in the subject.
An apparatus for modulating the neural activity of a CSC, SCG and/or postganglionic branch of a subject, the apparatus comprising:
- a neural interfacing element comprising one or more transducers each configured to apply an electrical signal to a CSC, SCG and/or postganglionic branch thereof of the subject and placed in signalling contact with a left cervical sympathetic chain (“CSC”), superior cervical ganglion (SCG) and/or postganglionic branch thereof each or a right cervical sympathetic chain (“CSC”), superior cervical ganglion (SCG) and/or postganglionic branch thereof;
- and
- a controller operably coupled to the one or more transducers, the controller controlling the signal to be applied by each of the one or more transducers, such that the signal stimulates increased localized sympathetic activity in the CSC, SCG and/or postganglionic branch in the subject.
A method for increasing sympathetic activity in a CSC, SCG and/or a postganglionic branch thereof of a subject:
- implanting in the subject at least a portion of an apparatus for modulating the neural activity of a CSC, SCG and/or postganglionic branch of a subject, the apparatus comprising:
- a neural interfacing element comprising one or more transducers each configured to apply an electrical signal to a CSC, SCG and/or postganglionic branch thereof of the subject and placed in signalling contact with a left cervical sympathetic chain (“CSC”), superior cervical ganglion (SCG) and/or postganglionic branch thereof each or a right cervical sympathetic chain (“CSC”), superior cervical ganglion (SCG) and/or postganglionic branch thereof;
- and
- i. a controller operably coupled to the one or more transducers, the controller controlling the signal to be applied by each of the one or more transducers, such that the signal stimulates increased localized sympathetic activity in the CSC, SCG and/or postganglionic branch in the subject;
- ii. positioning at least one transducer of the apparatus in signalling contact with the CSC, SCG and/or postganglionic branch thereof of the subject;
- and
- iii. activating the apparatus.
Dependencies are inferred from the claim text.