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US 2019/0054259 A1Published application
Liquid insulin formulations and methods relating thereto
AssigneeDance Biopharm Inc.
InventorsBlaine Bueche, Mei-Chang Kuo, John Patton, Matthew Sander
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Abstract
Liquid formulations of insulin that contain physically and chemically stable insulin but do not contain preservatives or stabilizers are provided. The formulations also lack surfactants. The formulations are useful for various modes of delivery including pulmonary delivery.
Claims42
An insulin formulation, comprising:
- insulin at a concentration of 1-13 mM;
- a salt at a concentration of 50-150 mM;
- a pH buffering agent at a concentration of 3-24 mM;
- zinc at a ratio of 1.9-2.7 zinc ions per insulin hexamer;
- and
- a pH in the range of 7.2 to 8.0,
- wherein the formulation does not contain preservatives or stabilizers.
4 more elements
Dependencies are inferred from the claim text.