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US 2019/0054166 A1Published application
Nanoparticles, controlled-release dosage forms, and methods for delivering an immunotherapeutic agent
AssigneeNorth Carolina State University
InventorsZhen Gu, Chao Wang, Yanqi Ye
Life of this patent
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Abstract
The present disclosure relates to nanoparticles, controlled-release dosage forms, and methods for the administration of an immunotherapeutic agent.
Claims23
A controlled-release pharmaceutical dosage form comprising:
- a CpG oligodeoxynucleotide nano-cocoon, wherein the nano-cocoon encapsulates an immunotherapeutic agent and inflammation-responsive nanoparticles, wherein the nanoparticles encapsulate a restriction enzyme.
-20. (canceled)
A nanoparticle comprising:
- hyaluronic acid covalently conjugated with 1-methyl-DL-tryptophan, wherein the nanoparticle encapsulates an immunotherapeutic agent.
-29. (canceled)
A method for treating or preventing a disease in a subject in need thereof, comprising:
- providing a microneedle patch to a subject, wherein the microneedle patch comprises:
- a plurality of microneedles each having a base end and a tip;
- a substrate to which the base ends of the microneedles are attached or integrated;
- nanoparticles, wherein the nanoparticles comprise hyaluronic acid covalently conjugated with 1-methyl-DL-tryptophan, and wherein the nanoparticles encapsulate an immunotherapeutic agent;
- inserting the microneedles into a biological barrier, wherein the immunotherapeutic is released into the subject in a controlled-release manner.
2 more elements
-36. (canceled)
Dependencies are inferred from the claim text.