Alpha-1-microglobulin for use in the protection of kidneys in connection with use of contrast media
AssigneeA1M Pharma AB
InventorsMartin AUSTIN, Magnus Göran GRAM, Bo ÅKERSTRÖM
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Abstract
This invention relates to an alpha-1-microglobulin for use in prevention of contras medium nephropathy.
Claims19
1-16. (canceled)
A method for treating or reducing the risks of side effects of medical contrast media, comprising administering an effective amount of alpha-1-microglobulin (A1M) to a subject in need thereof.
The method of claim 29, wherein the A1M has an amino acid sequence having the following amino acid residues at the following positions corresponding to the amino acid positions of human wildtype A1M set forth in SEQ ID NO:1:
- Y22
- C34
- K69
- K92
- K118
- K130
- Y132
- L180
- I181
- P182 and
- R183.
A kit comprising (a) alpha-1-microglobulin (AIM) and (ii) a medical contrast medium.
The kit of claim 31, wherein the A1M is provided in a pharmaceutical composition.
The kit of claim 34, wherein the A1M has an amino acid sequence having the following amino acid residues at the following positions corresponding to the amino acid positions of human wildtype A1M set forth in SEQ ID NO:1:
- Y22
- C34
- K69
- K92
- K118
- K130
- Y132
- L180
- I181
- P182 and
- R183.
Dependencies are inferred from the claim text.