Reducing conjugative plasmids in bacteria
AssigneeGangaGen, Inc.
InventorsChemira B. Appaiah, Jayasheela Manur, Bharathi Sriram
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Abstract
The present invention provides methods and compositions to reduce prevalence of plasmids in microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions. Means are provided to reduce the copy numbers of antibiotic resistance genes, and to confer phage binding to cells lacking receptors for those phage.
Claims5
A genetic construct comprising a segment encoding a phage receptor component driven by a strong heterologous promoter functional in a target bacterium which can serve as host to a lytic phage using said receptor.
A pharmaceutical composition comprising a transmissible DNA encoding a phage receptor which binds to a lytic phage, wherein said lytic phage will kill a bacterial cell expressing said phage receptor, and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.