Vaginal preparations for maintaining and/or restoring healthy female microbiota
AssigneeYun NV
InventorsSarah Lebeer, Ingmar Claes, Eline Oerlemans, Marianne Van Den Broek
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Abstract
The present invention is directed to the direct application of beneficial or probiotic bacteria to the vaginal niche for maintenance of a healthy vaginal microbiota and to help restore an unbalanced vaginal microbiota. The application is based on the use of selected Lactobacillus strains as anti-pathogenic agents, in particular L. pentosus and/or L. plantarum, against common vaginal pathogens, whereby produced acids such as lactic acid are important antimicrobial factors.
Claims16
1-13. (canceled)
A live Lactobacillus species for restoring or maintaining a healthy female microbiota by a topical vaginal route, the Lactobacillus species being selected from the group consisting of a L. pentosus strain having at least 97% sequence similarity with SEQ ID NO:
- 1 in its 16S rRNA gene and a L. plantarum strain having at least 97% sequence similarity with SEQ ID NO:
- 4 in its 16S rRNA gene.
A composition comprising one or more live Lactobacillus species that restores or maintains a healthy female microbiota, the Lactobacillus species being selected from the group consisting of a L. pentosus strain having at least 97% sequence similarity with SEQ ID NO:
- 1 in its 16S rRNA gene and a L. plantarum strain having at least 97% sequence similarity with SEQ ID NO:
- 4 in its 16S rRNA gene.
A method of probiotherapy, the method comprising:
- administering an effective amount of one or more live Lactobacillus species to a subject in need of the probiotherapy by a topical vaginal route, wherein at least one of the live Lactobacillus species is selected from the group consisting of a L. pentosus strain having at least 97% sequence similarity with SEQ ID NO:
- 1 in its 16S rRNA gene and a L. plantarum strain having at least 97% sequence similarity with SEQ ID NO:
- 4 in its 16S rRNA gene.
Dependencies are inferred from the claim text.