Compositions targeting senescent cells and the uses thereof
AssigneeBioVentures, LLC
InventorsDaohong Zhou, Guangrong Zheng, Xuan Zhang, Yingying Wang, Jianhui Chang, Fen Xia, Maria Schuller De Almeida, Ha-Neui Kim, Peiyi Zhang
Life of this patent
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Abstract
The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises a compound of Formula (I) or a compound of Formula (II). The selective killing of senescent cells may delay aging and/or treat age-related disorders.
Claims17
A method of treating chemotherapy induced peripheral neuropathy in a subject in need thereof, the method comprising administering a therapeutically-effective amount of at least one senolytic agent.
A method of selectively killing one or more senescent bone cells in a sample or subject in need thereof, the method comprising administering to the sample or subject a composition comprising a therapeutically effective amount of a compound comprising Formula (II):
- wherein
- R1 is selected from the group consisting of:
- R3 is absent, a bond, or a substituted or unsubstituted C1-C10 alkyl;
- A is absent, a bond, a substituted or unsubstituted C1-C6 aryl, a substituted or unsubstituted C1-C6cycloalkyl, or a substituted or unsubstituted C1-C6 heterocyclic group;
- R4 is a bond or a substituted or unsubstituted C1-C10 alky;
- n is an integer from 0 to 5,
- R2 is selected from the group consisting of
A method of treating or preventing osteoporosis in subject in need thereof, the method comprising administering to the sample or subject a composition comprising a therapeutically effective amount of a compound comprising Formula (II):
- wherein
- R1 is selected from the group consisting of:
- R3 is absent, a bond, or a substituted or unsubstituted C1-C10 alkyl;
- A is absent, a bond, a substituted or unsubstituted C1-C6 aryl, a substituted or unsubstituted C1-C6cycloalkyl, or a substituted or unsubstituted C1-C6 heterocyclic group;
- R4 is a bond or a substituted or unsubstituted C1-C10 alky;
- n is an integer from 0 to 5,
- R2 is selected from the group consisting of
Dependencies are inferred from the claim text.