Methods for attenuating parasite virulence
AssigneeInstituto De Medicina Molecular
InventorsLiliana Mancio SILVA, Maria Manuel DIAS DA MOTA
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Abstract
Pharmaceutical compositions and methods for the treatment of malaria are presented. Such compositions and methods may target energy-sensing pathways of the malaria parasite, Plasmoclium, of parasite host cell, or both. The compositions, in certain aspects of the present invention, target a signalling pathway involving the host AMP-protein activated kinase (AMPK) and/or the parasite AMPK homologue, KIN, which controls parasite replication and virulence.
Claims21
A method for attenuating proliferation of a Plasmodium organism in a host cell, comprising contacting the host cell with an effective amount of a 5′ AMP-activated protein kinase (AMPK) activating agent to attenuate the proliferation of the Plasmodium organism, wherein the AMPK activating agent activates a host cell AMPK, a Plasmodium AMPK homologue, or a host cell AMPK and a Plasmodium AMPK homologue.
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Dependencies are inferred from the claim text.