Methods used to treat cancer

A method of treating glioblastoma cells in a subject, the method comprising the steps of contacting the glioblastoma cells with a therapeutically effective amount of propentofylline or a pharmaceutically acceptable salt thereof and further contacting the glioblastoma cells with a pharmaceutical composition.

A pharmaceutical composition for the treatment of glioblastoma, the pharmaceutical composition comprising a therapeutically effective amount of first active ingredient comprising propentofylline or a pharmaceutically acceptable salt thereof and a second active ingredient.

A method of treating a patient with cancer, the method comprising the steps of:

• (a) sensitizing the patient to a treatment by reducing an expression level of PDZ-Rho Guanine Nucleotide Exchange Factor (RhoGEF) and
• (b) administering a therapeutically effective amount of the treatment to the patient.

A method of treating a patient with cancer, the method comprising the steps of:

• (a) administering a therapeutically effective amount of a first pharmaceutical composition comprising a TROY inhibitor or a pharmaceutically acceptable salt thereof to the patient with cancer;
• and
• (b) administering a therapeutically effective amount of a second pharmaceutical composition comprising an EGFR inhibitor or a pharmaceutically acceptable salt thereof to the patient with cancer.