Abuse-resistant pharmaceutical composition for the treatment of opioid dependence
AssigneeOrexo AB
InventorAndreas Fischer
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Abstract
There is provided pharmaceutical compositions for the treatment of e.g. opioid dependency comprising microparticles of a pharmacologically-effective amount of buprenorphine, or a pharmaceutically-acceptable salt thereof, in associative admixture with particles comprising a weak acid, or particles comprising weakly-acidic buffer forming materials. The composition may further comprise a disintegrant and/or particles of a pharmacologically-effective amount of naloxone, or a pharmaceutically-acceptable salt thereof. The compositions are useful in the treatment of opioid dependency/addiction and/or pain.
Claims24
A pharmaceutical composition in the form of a tablet suitable for sublingual administration, which comprises buprenorphine, or a pharmaceutically acceptable salt thereof, wherein the dose of buprenorphine (calculated as the free base) is 6 mg (±5%) and which, following administration, produces a mean area under the plasma concentration-time curve from time zero to the last concentration extrapolated to infinity based on the elimination rate constant for buprenorphine that is between 25 ng·h/mL and 40 ng·h/mL.
Dependencies are inferred from the claim text.