Pharmaceutical composition comprising pyrrolo-fused six-membered heterocyclic compound

A pharmaceutical composition, comprising:

• 1) 10-20 wt % of 5-(2-diethylamino-ethyl)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidene-methyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one or a pharmaceutically acceptable salt thereof, having a particle size distribution range d(0.9) thereof less than 60 μm;
• 2) 30-80 wt % of lactose or mannitol;
• 3) optionally 5-50 wt % of pregelatinized starch;
• 4) 1-30 wt % of a disintegrant, wherein the disintegrant is at least one selected from the group consisting of croscarmellose sodium, sodium carboxymethyl starch, low substituted hydroxypropyl cellulose and crospovidone;
• and
• 5) 0.5-5 wt % of a lubricant, wherein the lubricant is at least one selected from the group consisting of magnesium stearate, sodium stearyl fumarate, colloidal silicon dioxide, and talc.