Hsp90 targeted conjugates and particles and formulations thereof
AssigneeTarveda Therapeutics, Inc.
InventorsRajesh R. Shinde, Mark T. Bilodeau, Richard Wooster, Sudhakar Kadiyala
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Abstract
Conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to an HSP90 targeting moiety via a linker have been designed. Nanoparticles and microparticles comprising such conjugates can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or other diseases.
Claims48
A particle comprising a conjugate, wherein the conjugate comprises an active agent coupled to a HSP90 targeting moiety by a linker.
Dependencies are inferred from the claim text.