Immune boosting dietary compounds for disease control and prevention
AssigneeThe Board of Regents for Oklahoma State University Office of Intellectual Property Management
InventorGuolong Zhang
Life of this patent
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Abstract
Provided herein are small-molecule compounds and combinations thereof that enhance the synthesis of animal endogenous genus host defense peptides, which display potent antimicrobial and immunomodulatory activities. They thus represent alternatives to antibiotics for disease control and prevention for use in animals and humans. Examples of the small molecule compounds include histone deacetylase inhibitors, mono- and disaccharide sugars, cyclic adenosine monophosphate (cAMP) signaling agonists, and cyclooxygenase -2 (COX-2) inhibitors. Synergistic combinations include short-chain fatty acids, their chemical analogs or histone deacetylase inhibitors with other fatty acids, sugars, cAMP signaling agonists, and/or COX-2 inhibitors.
Claims23
A composition comprising
- i) a short-chain fatty acid or a chemical or functional analog thereof;
- and
- ii) at least one compound that is
- a different short-, medium- or long-chain fatty acid or chemical or functional analog thereof;
- a monosaccharide or a disaccharide,
- a cyclic adenosine monophosphate (cAMP) agonist, and/or
- a cyclooxygenase-2 inhibitor,
- with the caveat that the combination is not:
- butyrate and acetate and propionate, butyrate and forskolin, butyrate and cholera toxin, butyrate and pertussis toxin, benzyl butyrate and forskolin, glyceryl butyrate and forskolin, butyrate and lactose, or phenylbutyrate and lactose.
A method of synergistically increasing a level of expression of one or more genes encoding a host defense peptide in a subject, comprising
- administering to the subject a composition comprising
- i) a short-chain fatty acid or a chemical or functional analog thereof;
- and
- ii) at least one compound that is
- a different short, medium, or long-chain fatty acid or chemical or functional analog thereof;
- a monosaccharide or a disaccharide,
- a cyclic adenosine monophosphate (cAMP) agonist and/or
- a cyclooxygenase-2 inhibitor,
- wherein the composition is administered in an amount sufficient to increase the level of expression of one or more genes encoding the host defense peptides,
- with the caveat that the combination is not:
- butyrate and acetate and propionate, butyrate and forskolin, butyrate and cholera toxin, butyrate and pertussis toxin, benzyl butyrate and forskolin, glyceryl butyrate and forskolin, butyrate and lactose, or phenylbutyrate and lactose.
Dependencies are inferred from the claim text.