Antibacterial and antifungal compounds

A method of treating a bacterial infection caused by Gram-positive bacteria which is resistant to treatment with one or more other antibiotic agents in a subject, the method comprising administering to the subject in need thereof a therapeutically effective amount of a compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• ring A is selected from the group consisting of phenyl and naphthyl, each of which is optionally substituted by 1, 2, or 3 independently selected RA groups;
• each RA is independently selected from the group consisting of halo, OH, NO2, CN, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, cyano-C1-3 alkylene, HO—C1-3 alkylene, NH2, C1-4alkylamino, and di(C1-4 alkyl)amino;
• ring B is selected from the group consisting of phenyl and naphthyl, each of which is optionally substituted by 1, 2, 3, or 4 independently selected RB groups;
• and
• each RB is independently selected from the group consisting of halo, OH, NO2, CN, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, cyano-C1-3 alkyene, HO—C1-3 alkylene, NH2, C1-4alkylamino, di(C1-4 alkyl)amino, thio, —C(═O)N(di-C1-4 alkyl), —C(═O)NH(C1-4 alkyl), —C(═O)—C1-4 alkyl, —OC(═O)—C1-4 alkyl, —NHC(═O)—C1-4 alkyl, —C(═O)—C1-4 alkoxy, —C(═O)OH, —(CH═CH)—C(═O)OH, and —(CH═CH)—C(═O)—C1-4 alkoxy.

A pharmaceutical composition comprising:

• (i) a compound of Formula I:
• or a pharmaceutically acceptable salt thereof, wherein:
• ring A is selected from the group consisting of phenyl and naphthyl, each of which is optionally substituted by 1, 2, or 3 independently selected RA groups;
• each RA is independently selected from the group consisting of halo, OH, NO2, CN, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, cyano-C1-3 alkylene, HO—C1-3 alkylene, NH2, C1-4alkylamino, and di(C1-4 alkyl)amino;
• ring B is selected from the group consisting of phenyl and naphthyl, each of which is optionally substituted by 1, 2, 3, or 4 independently selected RB groups;
• and
• each RB is independently selected from the group consisting of halo, OH, NO2, CN, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, cyano-C1-3 alkylene, HO—C1-3 alkylene, NH2, C1-4alkylamino, di(C1-4 alkyl)amino, thio, —C(═O)N(di-C1-4 alkyl), —C(═O)NH(C1-4 alkyl), —C(═O)—C1-4 alkyl, —OC(═O)—C1-4 alkyl, —NHC(═O)—C1-4 alkyl, —C(═O)—C1-4 alkoxy, —C(═O)OH, —(CH═CH)—C(═O)OH, and —(CH═CH)—C(═O)—C1-4 alkoxy;
• (ii) at least one additional therapeutic agent, and
• (iii) a pharmaceutically acceptable carrier.

A method of killing or inhibiting growth of Gram-positive bacteria, the method comprising contacting the bacteria with an effective amount of a compound of Formula IV:

• or a pharmaceutically acceptable salt thereof, wherein:
• ring B is selected from the group consisting of phenyl and naphthyl, each of which is optionally substituted by 1, 2, 3, or 4 independently selected RB groups;
• and
• each RB is independently selected from the group consisting of halo, OH, NO2, CN, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, cyano-C1-3 alkylene, NH2, C1-4alkylamino, di(C1-4 alkyl)amino, thio, —C(═O)N(di-C1-4 alkyl), —C(═O)NH(C1-4 alkyl), —C(═O)—C1-4 alkyl, —OC(═O)—C1-4 alkyl, —NHC(═O)—C1-4 alkyl, —C(═O)—C1-4 alkoxy, —C(═O)OH, —(CH═CH)—C(═O)OH, and —(CH═CH)—C(═O)—C1-4 alkoxy.

A method of treating a bacterial infection caused by Gram-positive bacteria, the method comprising administering to the subject in need thereof a therapeutically effective amount of a compound of a compound of Formula IV:

• or a pharmaceutically acceptable salt thereof, wherein:
• ring B is selected from the group consisting of phenyl and naphthyl, each of which is optionally substituted by 1, 2, 3, or 4 independently selected RB groups;
• and
• each RB is independently selected from the group consisting of halo, OH, NO2, CN, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, cyano-C1-3 alkylene, NH2, C1-4alkylamino, di(C1-4 alkyl)amino, thio, —C(═O)N(di-C1-4 alkyl), —C(═O)NH(C1-4 alkyl), —C(═O)—C1-4 alkyl, —OC(═O)—C1-4 alkyl, —NHC(═O)—C1-4 alkyl, —C(═O)—C1-4 alkoxy, —C(═O)OH, —(CH═CH)—C(═O)OH, and —(CH═CH)—C(═O)—C1-4 alkoxy.