Self-assembled peptide nanofibers and use thereof for targeted drug delivery
AssigneesYissum Research Development Company of the Hebrew University of Jerusalem, Ramot at Tel-Aviv University Ltd.
InventorsGalia BLUM, Yael BEN-NUN, Ehud GAZIT, Lihi ADLER-ABRAMOVICH, Galit FICHMAN
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Abstract
Provided are peptide-based nanostructures, as well as diagnostic and therapeutic methods using same.
Claims20
A nanostructure comprising a plurality of peptides, at least a portion of the plurality of peptides comprises peptides having at least one pi-pi (π-π) interacting moiety and at least one protease interacting moiety, wherein the pi-pi interacting moiety and the at least one protease interacting moiety are different, wherein the at least one protease interacting moiety comprises at least one protease cleavable bond;
- and wherein the plurality of peptides is free of dipeptides.
A drug delivery system comprising a nanostructure and at least one drug associated therewith, wherein the nanostructure comprises a plurality of peptides, at least a portion of the plurality of peptides comprises peptides having at least one pi-pi (π-π) interacting moiety and at least one protease interacting moiety, wherein the pi-pi interacting moiety and the at least one protease interacting moiety are different, and wherein the at least one protease interacting moiety comprises at least one protease cleavable bond.
Dependencies are inferred from the claim text.