Sustained-release formulations of colchicine and methods of using same
AssigneeMurray and Poole Enterprises Ltd
InventorSusanne Riel
Life of this patent
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Abstract
Pharmaceutical compositions of colchicine for once-a-day oral administration are provided. The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined or desired release profile. Methods of treating or preventing cardiovascular disease and/or inflammatory disease in mammalian subjects comprising the administration of the novel formulations disclosed herein are also provided.
Claims21
A sustained release formulation of colchicine, comprising:
- (a) granules comprising 0.6 mg of colchicine or a pharmaceutically acceptable salt thereof and a binder;
- (b) a release retarding agent admixed with, or blended with, the granules, which comprises equal proportions of hydroxypropyl methylcellulose (HPMC) and lactose monohydrate;
- and
- (c) at least one pharmaceutically acceptable excipient admixed with, or blended with, the granules.
A homogenous sustained release composition, comprising:
- (a) granules comprising 0.6 mg of colchicine or a pharmaceutically acceptable salt thereof and a binder;
- (b) a release retarding agent admixed with, or blended with, the granules, which comprises equal proportions of hydroxypropyl methylcellulose (HPMC) and lactose monohydrate;
- (c) at least one pharmaceutically acceptable excipient admixed with, or blended with, the granules;
- and
- (d) optionally a coating.
Dependencies are inferred from the claim text.