Solid preparation
AssigneeTakeda Pharmaceutical Company Limited
InventorsWataru Hoshina, Masafumi Misaki
Life of this patent
Estimating the term…
Abstract
The present invention provides a solid preparation wherein variation in weight is suppressed, a solid preparation wherein the active ingredient is stabilized, and a stabilization method thereof. A solid preparation containing (1) an active ingredient, (2) D-mannitol and (3) an alkaline earth metal salt selected from magnesium aluminometasilicate and calcium silicate. A method of stabilizing the active ingredient, including adding an alkaline earth metal salt selected from magnesium aluminometasilicate and calcium silicate.
Claims8
A solid preparation comprising
- (1) 6-((7S)-7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide or a salt thereof,
- (2) D-mannitol and
- (3) an alkaline earth metal salt selected from magnesium aluminometasilicate and calcium silicate.
A method of stabilizing 6-((7S)-7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide or a salt thereof, comprising adding an alkaline earth metal salt selected from magnesium aluminometasilicate and calcium silicate to a solid preparation containing 6-((7S)-7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide or a salt thereof.
Dependencies are inferred from the claim text.