Method for preparing pharmaceutical composition comprising quinoline derivative or salt thereof

A method for preparing a pharmaceutical composition, comprising:

• mixing the active ingredient (R,E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)-propeneamide, or a pharmacologically acceptable salt thereof with a wetting agent to obtain a mixture, granulating the mixture to obtain granules, drying the granules to obtain dried granules, and tableting the dried granules into tablets or filling dried granules into capsules, wherein the wetting agent is a mixed solvent of ethanol and water, and wherein the ethanol is present in an amount of 50-80% by weight relative to the total weight of the wetting agent, and wherein the pharmaceutical composition further comprises:
• 1) 2-20 wt % of a disintegrant, wherein the disintegrant is cross-linked polyvinylpyrrolidone;
• 2) 5-80 wt % of a filler, wherein the filler is one or more selected from the group consisting of lactose and microcrystalline cellulose;
• 3) 0.5-15 wt % of a binder, wherein the binder is one or more selected from the group consisting of polyvinylpyrrolidone, hydroxypropyl methyl cellulose and hydroxypropyl cellulose;
• and
• 4) 0.5-5 wt % of a lubricant, wherein the lubricant is one or more selected from the group consisting of magnesium stearate and talc.