Sustained release cyclosporine-loaded microparticles
AssigneeMidatech Pharma (Wales) Limited
InventorsPaul Seaman, Katherine Bamsey, Nigel Thomas, Dewi Paice
Life of this patent
Estimating the term…
Abstract
A controlled release pharmaceutical formulation is provided, comprising cyclosporine-loaded microparticles of a bioresorbable polymer comprising poly(D,L-lactide), wherein the mean diameter of the microparticles is in the range 20 μm to 40 μm. Also provided are medical uses of the pharmaceutical formulation, in particular in the treatment of uveitis, a process for production of the pharmaceutical formulation and injectable dosage forms, including those formulated for intravitreal injection.
Claims35
A controlled release pharmaceutical formulation comprising cyclosporine-loaded microparticles of a bioresorbable polymer comprising poly(D,L-lactide), wherein the mean diameter of the microparticles is in the range 20 μm to 40 μm, and wherein the formulation comprises said microparticles suspended in a liquid vehicle, which liquid vehicle has a viscosity of between 30 and 45 mPas as measured at 20° C. using an A&D SV-1a vibro viscometer (A&D Instruments Ltd) according to the manufacturer's instructions, and wherein the formulation comprises a thixotropic agent selected from the group consisting of:
- hypromellose, hydroxyethyl cellulose, hydrophillically-modified hydroxyethyl cellulose, Xanthan Gum, Guar Gum, and Cetyl alcohol, and wherein the liquid formulation exhibits shear-thinning behaviour such that the viscosity decreases under shear strain.
(canceled)
-12. (canceled)
-25. (canceled)
-34. (canceled)
-44. (canceled)
-47. (canceled)
-51. (canceled)
Dependencies are inferred from the claim text.