Methods for using regulators for increasing the expression or activation of p53 and/or regulators for reducing or inhibiting the expression of p63-alpha, for the treatment of non-alcoholic fatty liver disease (nafld) and/or non-alcoholic steatohepatitis (nash)
OwnerRubén NOGUIERAS POZO, Carlos DIÉGUEZ GONZALEZ +1inventors
InventorsRubén NOGUIERAS POZO, Carlos DIÉGUEZ GONZALEZ, Mabel LOZA GARCÍA
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Abstract
The invention relates to a regulator for increasing the expression of the p53 protein in hepatocyte cells and/or a regulator for reducing or inhibiting the expression of the p63α protein in hepatocyte cells, for the production of a drug for use in the treatment of non-alcoholic fatty liver disease (NAFLD) and/or non-alcoholic steatohepatitis (NASH).
Claims20
A pharmaceutical composition comprising a compound capable of up-regulating the expression of p53 and/or down-regulating or inhibiting the expression of p63 in the hepatocyte cells of a human subject suffering from non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH), in relation to that observed in the absence of the agent, for use in the prophylactic or therapeutic treatment of non-alcoholic fatty liver disease (NAFLD) and/or non-alcoholic steatohepatitis (NASH).
Dependencies are inferred from the claim text.