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US 2019/0054010 A1Published application
Formulation and aerosol canisters, inhalers, and the like containing the formulation
Assignee3M Innovative Properties Company
InventorsALEXANDER D. SLOWEY, PHILIP M. COCKS, SARAH J. DEXTER
Life of this patent
Estimating the term…
Abstract
Compositions containing tiotropium or a pharmaceutically acceptable salt or solvate thereof, citric acid or a salt thereof, glycerol, ethanol, and a propellant, as well as aerosol canisters and inhalers containing the same. Methods of manufacturing and using the compositions, aerosol canisters, and inhalers.
Claims15
A composition comprising
- tiotropium or a pharmaceutically acceptable salt or solvate thereof in a concentration of 0.0075 wt % to 0.015 wt % based on the weight of tiotropium bromide;
- citric acid or a salt thereof in a concentration greater than 0.10 wt % and no greater than 0.2 wt % based on the weight of free citric acid;
- glycerol in a concentration of 0.5 wt % to 2.0 wt %;
- ethanol in a concentration of up to 20 wt %;
- and
- a propellant consisting essentially of 1,1,1,2-tetrafluoroethane;
- wherein the formulation is a solution.
4 more elements
Dependencies are inferred from the claim text.