Melanin Decomposition Inhibitor
AssigneeKao Corporation
InventorsDaiki MURASE, Akira HACHIYA, Naoki OYA, Kei TAKANO, Akiko KAWASAKI, Keigo KAWABATA
Life of this patent
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Abstract
To provide an inhibitor of melanin decomposition, which inhibits decomposition of melanin in keratinocytes to accelerate accumulation of melanin in skin and hair. An inhibitor of melanin decomposition in keratinocytes, comprising at least one selected from the group consisting of a plant extract containing berberine or a salt thereof, berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof, as an active ingredient.
Claims21
An inhibitor of melanin decomposition in keratinocytes, comprising at least one selected from the group consisting of berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof as an active ingredient.
An inhibitor of autophagy in keratinocytes, comprising at least one selected from the group consisting of berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof as an active ingredient.
An agent for darkening skin or hair color, comprising at least one selected from the group consisting of berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof as an active ingredient.
An agent for preventing and improving gray hair, comprising at least one selected from the group consisting of berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof as an active ingredient.
An external preparation for skin, comprising proguanil or a salt thereof.
A method for inhibiting melanin decomposition in keratinocytes, comprising administrating to or ingesting in a subject in need thereof, at least one selected from the group consisting of berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof in an effective amount.
A method for inhibiting autophagy in keratinocytes, comprising administrating to or ingesting in a subject in need thereof, at least one selected from the group consisting of berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof in an effective amount.
A method for darkening skin or hair color, comprising administrating to or ingesting in a subject in need thereof, at least one selected from the group consisting of a berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof in an effective amount.
A method for preventing or improving gray hair, comprising administrating to or ingesting in a subject in need thereof, at least one selected from the group consisting of berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof in an effective amount.
Dependencies are inferred from the claim text.