Micro and nanoparticulate compositions comprising anti-microbially active groups
AssigneesNobio Ltd., Hadasit Medical Research Services and Development Ltd.
InventorsNathan ZALTSMAN, Ervin I. WEISS
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Abstract
The present invention relates to anti-microbially active micro and nanoparticles, compositions comprising same, and use thereof for inhibiting bacterial growth and biofilm formation on surfaces or devices, e.g., dental surfaces or devices. The present invention further discloses methods of making such anti-microbially active micro or nanoparticles.
Claims53
A positively charged particle represented by the following structure (1):
- wherein
- the core is an inorganic material, a metal or a metal oxide;
- L1 is a linker or a bond;
- R1 is alkyl, terpenoid moiety, cycloalkyl, aryl, heterocycle, a conjugated alkyl, alkenyl, alkynyl or any combination thereof;
- R2 is alkyl, terpenoid moiety, cycloalkyl, aryl, heterocycle, a conjugated alkyl, alkenyl, alkynyl or any combination thereof;
- R3 is hydrogen, alkyl, terpenoid moiety, cycloalkyl, aryl, heterocycle, a conjugated alkyl, alkenyl, alkynyl or any combination thereof;
- X is a bond, alkyl, alkenyl or alkynyl;
- X′ is nothing or hydrogen;
- and
- p is the number of chains per one sq nm (nm2) of the core surface, wherein the anti microbial active group is at a surface density of between 0.001-20 anti microbial active groups per one sq nm (nm2) of the core surface;
- wherein if L1 and X are bonds, then the nitrogen is part of the core;
- and
- at least one of R1, R2, R3 is alkyl, conjugated alkyl alkenyl or alkynyl having at least four carbons;
- or terpenoid moiety, cycloalkyl, aryl or heterocycle having at least six carbons.
6-13. (canceled)
(canceled)
-25. (canceled)
The composition of claim 25, wherein said matrix is a polymeric matrix comprising a thermoplastic polymer.
A packaging composition comprising the composition of claim 25.
-32. (canceled)
The composition of claim 25, wherein the composition is a pharmaceutical composition, wherein the composition is in a form selected from the group consisting of a cream, an ointment, a paste, a dressing and a gel or wherein the composition is formulated for topical application or administration.
(canceled)
(canceled)
40-59. (canceled)
A positively charged particle represented by the following structure (1):
- wherein
- the core is an organic polymeric material;
- L1 is a linker or a bond;
- R1 is alkyl, terpenoid moiety, cycloalkyl, aryl, heterocycle, a conjugated alkyl, alkenyl, alkynyl or any combination thereof;
- R2 is alkyl, terpenoid moiety, cycloalkyl, aryl, heterocycle, a conjugated alkyl, alkenyl, alkynyl or any combination thereof;
- R3 is hydrogen, alkyl, terpenoid moiety, cycloalkyl, aryl, heterocycle, a conjugated alkyl, alkenyl, alkynyl or any combination thereof;
- X is a bond, alkyl, alkenyl or alkynyl;
- X′ is nothing or hydrogen;
- and
- p is the number of chains per one sq nm (nm2) of the core surface, wherein the anti microbial active group is at a surface density of between 0.001-20 anti microbial active groups per one sq nm (nm2) of the core surface;
- wherein if L1 and X are bonds, then the nitrogen is an part of the core;
- wherein at least one of R1, R2, R3 is alkyl, conjugated alkyl alkenyl or alkynyl having at least four carbons;
- or terpenoid moiety, cycloalkyl, aryl or heterocycle having at least six carbons;
- and
- at least one of R1, R2, R3, is a terpenoid moiety.
Dependencies are inferred from the claim text.