Biosensor for multi-analyte characterization
AssigneeInternational Business Machines Corporation
InventorsHARIKLIA DELIGIANNI, BRUCE B. DORIS, STEVEN J. HOLMES, QINGHUANG LIN, ROY R. YU
Life of this patent
Estimating the term…
Abstract
Embodiments of the present invention are directed to a semiconductor device. A non-limiting example of the semiconductor device includes a semiconductor substrate. The semiconductor device also includes a plurality of metal nanopillars formed on the substrate. The semiconductor device also includes an amperometric sensor associated with one of the plurality of nanopillars, wherein the amperometric sensor is selective to an enzyme-active neurotransmitter. The semiconductor device also includes a resistivity sensor associated with a pair of nanopillars, wherein the resistivity sensor is selective to an analyte.
Claims25
A method of fabricating a semiconductor device, the method comprising:
- forming a plurality of nanopillars on a substrate, the plurality of nanopillars comprising a first nanopillar and a pair of adjacent nanopillars;
- forming an insulating layer on the plurality of nanopillars to generate a plurality of lined nanopillars;
- removing the insulating layers from upper portions of the pair of adjacent nanopillars to generate exposed adjacent nanopillar portions;
- forming a resistivity sensor on the exposed adjacent nanopillar portions;
- removing the insulating layer from the first nanopillar to generate an exposed first nanopillar portion;
- forming an amperometric sensor on the exposed first nanopillar portion.
A semiconductor device comprising:
- a semiconductor substrate;
- a plurality of metal nanopillars formed on the substrate;
- an amperometric sensor associated with one of the plurality of nanopillars, wherein the amperometric sensor is selective to an enzyme-active neurotransmitter;
- and
- a resistivity sensor associated with a pair of nanopillars, wherein the resistivity sensor is selective to an analyte.
A multi-analyte biosensor comprising:
- a substrate;
- a first nanopillar comprising a base connected to the substrate;
- a second nanopillar comprising a base connected to the substrate, wherein the second nanopillar is adjacent to the first nanopillar;
- an imprinted polymer physically contacting at least a portion of the first nanopillar and at least a portion of the second nanopillar, wherein the imprinted polymer comprises a conductive porous polymer comprising a plurality of cavities with affinity to a first analyte;
- and
- a third nanopillar comprising a base connected to the substrate, wherein the third nanopillar is lined with an amperometric sensor polymer comprising a plurality of binding sites with affinity to a second analyte.
A multi-analyte biosensor comprising:
- a semiconductor substrate;
- a first sensing region comprising a first plurality of nanopillars connected to a first conductive polymer selective to a first biomolecule, wherein the first sensing region is connected to the semiconductor substrate;
- a second sensing region comprising a second plurality of nanopillars connected to a second conductive polymer selective to a second biomolecule, wherein the second sensing region is connected to the semiconductor substrate and wherein the second biomolecule is different than the first biomolecule;
- an interface layer connecting the semiconductor substrate to a processor;
- and
- a communications interface.
A computer-implemented method of multi-analyte detection, the method comprising:
- receiving, to a processor, a signal from a multi-analyte sensor in contact with a biological tissue, wherein the multi-analyte sensor comprises a resistivity sensor and an amperometric sensor;
- determining, by the processor, a resistivity value from the resistivity sensor;
- generating, by the processor, a concentration of a first analyte based at least in part upon the resistivity value;
- determining, by the processor, an electrical current from the amperometric sensor;
- and
- generating, by the processor, a concentration of a second analyte based at least in part upon the electrical current.
Dependencies are inferred from the claim text.