Process and intermediates for the production of 17(20)-ene b-seco steroids
AssigneePatheon Austria GmbH & Co KG
InventorsGeorge Petros YIANNIKOUROS, Panos KALARITIS, Denis Viktorovich AREFYEV
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Abstract
The invention pertains to a process for producing a compound of formula (11) wherein R7 and R8 are each independently selected from H, halogen, alkyl, aryl, or alkylaryl, R42 is H or a protective group, R43 is H or R3, wherein R3 is a protective group, by contacting a compound of formula (10) with an olefmation reagent, wherein compound of formula (10) comprises a counter acid X1 when R42═H and R43═H.
Claims15
A process for producing a compound of formula (11)
- wherein R7 and R8 are each independently selected from H, halogen, alkyl, aryl, or alkylaryl, R42 is H or a protective group, R43 is H or R3, wherein R3 is a protective group, by contacting a compound of formula (10)
- with an olefination reagent, wherein compound of formula (10) comprises a counter acid X1 when R42═H and R43═H.
Process according to claim further comprising a step of contacting a compound of formula (3)
- wherein R1, R2 and R3 are protective groups, with a second oxidizing agent to obtain a compound of formula (4)
A process for preparing a compound of formula (4)
- wherein R1, R2 and R3 are protective groups, comprising the step of contacting a compound of formula (3)
- with a second oxidizing agent to obtain the compound of formula (4).
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A compound of formula (5)
- wherein R1, R2, R3 and R4 are protective groups.
A compound of formula (6)
- wherein R1, R2 and R3 are protective groups, and R5 is H or a protective group.
A compound of formula (7)
- wherein R1, R2 and R3 are protective groups.
A compound of formula (8)
- wherein R1, R2 and R3 are protective groups and R6 is either H or —OR22, wherein R22 is either H or a protective group.
A compound of formula (9)
- wherein R1, R2 and R3 are protective groups.
(canceled)
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Dependencies are inferred from the claim text.