Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using elisa assays
AssigneeBoard of Regents, The University of Texas System
InventorsMaher ALBITAR, Michael J. KEATING, Taghi MANSHOURI
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Abstract
The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.
Claims25
-3. (canceled)
A method of an immunotherapy comprising administering to a patient a therapeutic antibody and detecting the presence of a circulating antibody:antigen complex.
(canceled)
A method of detecting a therapeutic antibody:antigen complex comprising:
- obtaining a sample from a patient, wherein the patient has undergone a course of immunotherapy with a therapeutic antibody in which the therapeutic antibody binds to a soluble circulating target antigen forming the complex;
- contacting the sample with a first monoclonal antibody, wherein the antibody captures the complex;
- contacting the complex with a labeled second antibody;
- and
- measuring the labeled complex.
-12. (canceled)
-19. (canceled)
-32. (canceled)
A method of monitoring an autoimmune disease comprising measuring a therapeutic antibody:antigen complex in the patient serum.
-73. (canceled)
Dependencies are inferred from the claim text.