Novel nucleic acid molecules
AssigneeCure Vac SE
InventorsMariola Fotin-Mleczek, Katja Fiedler, Aleksandra Kowalczyk, Regina Heidenreich
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Abstract
The present invention provides novel artificial nucleic acid molecules encoding at least one antigenic peptide or protein and at least one additional sequence preferably targeting the antigenic peptides or proteins to cellular compartments of interest. Further, the invention provides (pharmaceutical) compositions or vaccines and kits comprising said nucleic acid molecules. The nucleic acid molecules, (pharmaceutical) compositions or vaccines and kits are useful for treating a variety of diseases such as cancer, infectious diseases, autoimmune diseases, allergies or graft-versus host disease.
Claims24
An artificial nucleic acid molecule comprising at least one coding region encoding
- a. at least one antigenic peptide or protein,
- and at least one additional amino acid sequence derived from at least one immune response activating signal transduction protein located in the external plasma membrane,
- wherein said at least one additional amino acid sequence comprises or consists of at least one transmembrane domain.
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Dependencies are inferred from the claim text.