High Throughput Methods for Screening Chemical Reactions Using Reagent-Coated Bulking Agents
AssigneeAbbVie Inc.
InventorsAmanda Dombrowski, Noah P. Tu, Ying Wang
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Abstract
Systems, methods, and compositions for high throughput screening of micro-scale chemical reactions are disclosed. In particular, systems, methods, and compositions for handling small amounts of solid reagent are disclosed. For example, mechanical mixing is employed to obtain reagent-coated bulking agents that can be used, inter alia, in high throughput methods for screening micro-scale chemical reactions.
Claims20
A solid substrate comprising an outer surface and at least one reagent for chemical synthesis attached to the outer surface, wherein the reagent for chemical synthesis is attached to the outer surface by an application of mechanical energy to a mixture comprising the reagent for chemical synthesis and the solid substrate.
The solid substrate of any one of the preceding claims, wherein the reagent for chemical synthesis is selected from the group consisting of a reactant, a transition metal source, a coupling ligand, a base, and combinations thereof.
The solid substrate of any one of the preceding claims, wherein the reagent for chemical synthesis is present in an amount from about 1% to about 20% (w/w).
A method for making a reagent-coated bulking agent comprising the steps of:
- (a) combining a reagent and a bulking agent to form a mixture;
- and
- (b) applying mechanical energy to the mixture.
A method for dispensing at least one reagent for chemical synthesis comprising the steps of:
- (a) providing a reagent-coated bead, wherein at least one reagent for chemical synthesis is attached to an outer surface of the bead via an application of mechanical energy to a mixture comprising the reagent for chemical synthesis and an uncoated bead;
- and
- (b) dispensing the reagent-coated bead to a reaction vessel.
Dependencies are inferred from the claim text.