Usp10 modulation of ampk and mtor
AssigneeMayo Foundation for Medical Education and Research
InventorsZhenkun LOU, Min DENG, Bo QIN
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Abstract
Materials and methods for modulating activity of kinases such as AMPK and mTOR via the deubiquitinase, USP10, are provided herein. Also provided are materials and methods for treating clinical conditions mediated at least in part by such kinases, including obesity, diabetes, metabolic syndrome, and some cancers.
Claims36
A method for increasing the activity of AMP-activated protein kinase (AMPK) in a cell, comprising contacting the cell with an agent effective to increase the level or deubiquitinase activity of USP10 in the cell.
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A method for reducing the activity of mammalian target of rapamycin (mTOR) in a cell, comprising contacting the cell with an agent effective to increase the level or deubiquitinase activity of USP10 in the cell.
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A method for increasing the activity of AMPK in a cell, comprising contacting the cell with an agent effective to increase, in the cell, the level of an AMPK polypeptide that lacks one or more ubiquitination sites.
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Dependencies are inferred from the claim text.