Method for incubating liquids
AssigneeBaxalta Incorporated
InventorsNikolaus HAMMERSCHMIDT, Jure SENCAR, Alois JUNGBAUER, Duarte Lima MARTINS
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Abstract
The present invention relates a method for incubating liquids, to a method for preparing a biopharmaceutical drug, and to a device for the preparation of a biopharmaceutical drug.
Claims31
A method for incubating a mixture of at least two liquids, the method comprising:
- i) mixing said at least two liquids to obtain a mixture;
- and
- ii) passing said mixture through a structure having multiple interconnected channels, thereby incubating said mixture.
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A device for the preparation of a biopharmaceutical drug, the device comprising a packed bed of non-porous beads, wherein the device comprises at least one of:
- a) non-porous beads comprising a mean particle diameter in the range of 0.05-1 mm, 0.05-0.6 mm, 0.05-0.5 mm, or 0.05-0.3 mm;
- b) non-porous beads that do not deviate from a mean particle diameter by more than 50%, more than 35%, or more than 20%;
- or
- c) the packed bed of non-porous beads has a length of at least 5 cm, at least 10 cm, at least 20 cm, at least 30 cm, at least 50 cm, at least 70 cm, or at least 100 cm.
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A method for modification of a continuous-flow virus inactivation process, wherein the modification comprises using a structure having multiple interconnected channels for continuous-flow virus inactivation, and passing a mixture of at least two liquids through said structure, thereby incubating said mixture for virus inactivation and wherein said continuous-flow virus inactivation process is optionally a process for the preparation of a biopharmaceutical drug.
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Dependencies are inferred from the claim text.