Multimodal trail molecules and uses in cellular therapies
AssigneeThe General Hospital Corporation
InventorKhalid Shah
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Abstract
Described herein are novel compositions comprising multimodal TRAIL agents and cells engineered to express such multimodal TRAIL agents, including cells encapsulated in a scaffold or matrix, for use in the treatment of disorders such as cancer.
Claims22
-22. (canceled)
A composition comprising a T cell comprising a nucleic acid encoding a polypeptide comprising a soluble TRAIL fusion protein comprising a reporter module, a linker module, and a therapeutic TRAIL module comprising an extracellular domain of human TRAIL of SEQ ID NO:
- 1.
A composition comprising a T cell comprising a heterologous nucleic acid sequence encoding a soluble TRAIL polypeptide comprising an extracellular domain of human TRAIL of SEQ ID NO:
- 1, wherein the cell is encapsulated in a matrix or scaffold.
Dependencies are inferred from the claim text.