Hybrid membrane-coated nanoparticle composites and methods of making and using the same
AssigneePortland State University
InventorMarilyn Mackiewicz
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Abstract
Disclosed herein are embodiments of nanoparticle composites that comprise covalently coupled stabilizing agent molecules that improve stability of the nanoparticle composites and allow for tight packing of lipids and/or membranes. The nanoparticle composites can further comprise inhibition inhibitors and/or lipid components that interact to form a hybrid lipid bilayer membrane around the nanoparticle core. The nanoparticle composites can be coupled to drugs, targeting moieties, and imaging moieties. The nanoparticle composites can be used for in vivo drug deliver, disease diagnosis/treatment, and imaging.
Claims22
A nanoparticle composite, comprising:
- one or more lipid molecules;
- one or more aggregation inhibitors;
- one or more stabilizing agent molecules comprising a heteroatom group and an aliphatic chain;
- and
- a nanoparticle core, comprising iron, silver, gadolinium, or a combination or oxide thereof;
- wherein the nanoparticle core is covalently coupled to the one or more stabilizing agent molecules through the heteroatom group of the one or more stabilizing agent molecules.
A method of using a nanoparticle composite, comprising:
- selecting a shape of a nanoparticle core component of the nanoparticle composite so as to influence a wavelength at which the nanoparticle composite will absorb energy;
- administering the nanoparticle composite to a subject or a sample;
- and
- detecting the presence of the nanoparticle composite in the subject or the sample using an energy source that produces energy at the wavelength at which the nanoparticle composite will absorb.
A method of making a lipid-containing nanoparticle composite, comprising:
- selecting a pre-determined number or proportion of stabilizing agent molecules, aggregation inhibitors, or combination thereof that will populate a surface of a nanoparticle core;
- and
- matching the number of lipid molecules used to make the lipid-containing nanoparticle composite to the pre-determined number or proportion of stabilizing agent molecules, aggregation inhibitors, or combination thereof to thereby avoid excess lipid molecules that are not part of a lipid-containing nanoparticle and that otherwise would be contained in the reaction mixture after the surface is populated.
Dependencies are inferred from the claim text.