US 2019/0002942 A1 · ANTIBIOTIC FIIRV 104/18 COMPLEX AND THE ISOLATED INDIVIDUAL FACTORS THEREOF

Abstract

An antibiotic FIIRV 104/18 complex comprising factors F793, F795, F797, F813 and F683, of formula (I), wherein R represents a glycosidic radical as defined in the specification, the isolated individual factors, a method for their production by cultivation of Dactylosporangium FIIRV sp. 104/18 DSM 32068 under aerobic conditions, and pharmaceutical formulations containing them as active ingredient and their use in the treatment of bacterial infections, caused by bacteria of at least one of the genera Enterococci, Streptococci, Staphylococci and Moraxella, including bacteria of multi resistant strains, in particular Staphylococcus spp., Streptococcus spp, and Enterococcus spp. resistant to methicillin and/or vancomycin.

Claims18

Dependent claims

1-6. (canceled)

A process for the preparation of an antibiotic FIIRV 104/18 complex of formula (I),

comprising factors F793, F795, F797, F813 and F683
wherein
R represents
or one or more of the isolated individual factors:
factor F793 of formula
factor F795 of formula
factor F797 of formula
factor F813 of formula
or
factor F683 of formula
the process comprising
(a) cultivating Dactylosporangium FIIRV sp. 104/18 DSM 32068, or a variant or mutant thereof maintaining the ability to produce the antibiotic of formula (I), under aerobic conditions, in an aqueous nutrient medium containing usable sources of carbon, nitrogen and inorganic salts;
(b) isolating the resulting antibiotic of formula (I) from the whole fermentation broth, or from the separated mycelium or from the filtered or centrifuged fermentation broth;
(c) purifying the isolated antibiotic of formula (I).

11 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/780,644Filed 24 Nov 2016

Priority

EP 15197443.32 Dec 2015

Published

3 Jan 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

C12P 19/28
Preparation of nitrogen-containing carbohydrates: n-glycosides
A61K 9/0014
Galenical forms characterised by the site of application: skin, i.e. galenical aspects of topical compositions
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 9/0053
Galenical forms characterised by the site of application: mouth and digestive tract, i.e. intraoral and peroral administration

Antibiotic fiirv 104/18 complex and the isolated individual factors thereof

Life of this patent

Antibiotic fiirv 104/18 complex and the isolated individual factors thereof

Life of this patent

Abstract

Claims18