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AssigneeThe Research Foundation for The State University of New York
InventorsEckard Wimmer, Steffen Mueller, Bruce Futcher, Sam Shen, Charles Stauft, Charles Ward
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This invention provides an attenuated virus comprising a modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein encoding sequence relative to a first host while the codon pair bias relative to a second host is not substantially reduced. In another embodiment, the invention provides an attenuated virus comprising modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein-encoding sequence relative to a first host and a second host. The attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the attenuated virus.
An attenuated virus comprising a viral genome having one or more modified virus protein-encoding sequences wherein the codon pair bias, relative to a first host, of at least one virus protein-encoding sequence is less than the codon pair bias of the parent nucleic acid sequence from which it is derived, and wherein the codon pair bias of the one or more modified virus protein-encoding sequences is not substantially reduced relative to that of a second host.
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24-43. (canceled)
45-66. (canceled)
Dependencies are inferred from the claim text.