Compositions for application to wounds

A composition for application to a wound comprising:

• a first layer comprising a skin adhesive comprising a substance selected from a silicone, a hydrocolloid, a polyurethane, an acrylic polymer, a rubber adhesive and a hydrogel, the hydrogel being a hydrogel with low water absorption,
• wherein the first layer has a wound-facing side and a non-wound-facing side and, in a first area, apertures extend through the first layer from the wound-facing side to the non-wound-facing side, the first layer having a second area forming a perimeter around the first area, the perimeter lacking apertures therethrough, and, in-use, the wound facing side of the first layer would contact a wound,
• wherein the mean area of the apertures on at least one of the wound-facing side and non-wound-facing side of the first layer is at least 20 mm2;
• and
• a second layer disposed on a non-wound-facing side of the first layer, the second layer being an outermost layer of the composition, the second layer comprising a polymeric film that is continuous in that it extends over and covers each of the apertures of the first layer, the second layer having a moisture vapour transmission rate (MVTR) of at least 500 g/m2/24 hours, measured in accordance with BS EN 13726-2:2002,
• wherein the composition further comprises a third layer disposed between the first layer and second layer, the third layer being a supporting layer for the first layer, the third layer having apertures therethrough, substantially corresponding to the apertures in the first layer.

A method of forming a composition for application to a wound comprising

• providing a first layer comprising a skin adhesive with low water absorption,
• wherein the first layer has a wound-facing side and a non-wound-facing side and, in a first area, apertures extend through the first layer from the wound-facing side to the non-wound-facing side, the first layer having a second area forming a perimeter around the first area, the perimeter lacking apertures therethrough,
• wherein the mean area of the apertures on at least one of the wound-facing side and non-wound-facing side of the first layer is at least 20 mm2,
• the first layer being disposed on a third layer, the third layer being a supporting layer for the first layer and having apertures therethrough substantially corresponding to the apertures of the first layer,
• associating a second layer with the first and third layers, such that the third layer is disposed between the first and second layers, the second layer being an outermost layer of the composition, and, in-use, the wound facing side of the first layer would contact a wound, the second layer comprising a polymeric film that is continuous in that it extends over and covers each of the apertures of the first layer, the second layer having a moisture vapour transmission rate (MVTR) of at least 500 g/m2/24 hours, measured in accordance with BS EN 13726-2:2002.

A method of forming a composition for application to a wound comprising

• providing a first layer comprising a skin adhesive comprising a substance selected from a silicone, a hydrocolloid, a polyurethane, a rubber adhesive, an acrylic polymer, and a hydrogel, the hydrogel being a hydrogel with low water absorption,
• wherein the first layer has a wound-facing side and a non-wound-facing side and, in a first area, apertures extend through the first layer from the wound-facing side to the non-wound-facing side, the first layer having a second area forming a perimeter around the first area, the perimeter lacking apertures therethrough,
• wherein the mean area of the apertures on at least one of the wound-facing side and non-wound-facing side of the first layer is at least 20 mm2,
• the first layer being disposed on a third layer, the third layer being a supporting layer for the first layer and having apertures therethrough substantially corresponding to the apertures of the first layer.
• associating a second layer with the first and third layers, such that the third layer is disposed between the first and second layers, the second layer being an outermost layer of the composition, and, in-use, the wound facing side of the first layer would contact a wound, the second layer comprising a polymeric film that is continuous in that it extends over and covers each of the apertures of the first layer, the second layer having a moisture vapour transmission rate (MVTR) of at least 500 g/m2/24 hours, measured in accordance with BS EN 13726-2:2002.