Hiv replication inhibitor

5:

• The compound according to claim 1 or its pharmaceutically acceptable salt, wherein ring A is monocyclic aromatic carbocycle, monocyclic non-aromatic carbocycle, monocyclic aromatic heterocycle or monocyclic non-aromatic heterocycle,
• wherein the ring may be fused with another aromatic carbocycle, non-aromatic carbocycle, aromatic heterocycle, or non-aromatic heterocycle;
• the ring may form a spiro ring together with another aromatic carbocycle, non-aromatic carbocycle, aromatic heterocycle or non-aromatic heterocycle;
• two atoms constituting ring A which are not adjacent to each other may be cross-linked with alkylene, alkenylene or alkynylene;
• and/or, rings may be substituted with one or more of RA;
• wherein RA is each independently, halogen, cyano, nitro, oxo, azide, trimethylsilyl or —XA—RA1;
• XA is a single bond, —O—, —S—, —NRA2—, ═N—, —CO—, —SO2—, —O—CO—, —CO—O—, —NRA2—CO—, —CO—NRA2—, —NRA2—CO—O—, —CO—O—NRA2—, —O—CO—NRA2—, —NRA2—O—CO—, —CO—NRA2—O—, —O—NRA2—CO—, —NRA2—CO—NRA3—, —NRA2—SO2— or —SO2—NRA2—;
• RA1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl, provided that when XA is a single bond, RA1 is not a hydrogen atom;
• RA2 and RA3 are each independently a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl;
• when XA is —NRA2—, —CO—NRA2—, —CO—O—NRA2—, —O—CO—NRA2— or —SO2—NRA2—, RA1 and RA2 may be taken together with an adjacent nitrogen atom to form substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• when XA is —NRA2—CO—NRA3—, RA1 and RA3 may be taken together with an adjacent nitrogen atom to form substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• R1 and RA may be taken together with an adjacent atom to form aromatic carbocycle, non-aromatic carbocycle, aromatic heterocycle or non-aromatic heterocycle, wherein the ring may be substituted with one or more of the same or different RA;
• wherein RA′ is each independently, halogen, cyano, nitro, oxo, azide, trimethylsilyl or —XA′—RA′1;
• XA′ is a single bond, —O—, —S—, —NRA′2—, ═N—, —CO—, —SO2—, —O—CO—, —CO—O—, —NRA′2—CO—, —CO—NRA′2—, —NRA′2—CO—O—, —CO—O—NRA′2, —O—CO—NRA′2—, —NRA′2—O—CO—, —CO—NRA′2—O—, —O—NRA′2—CO—, —NRA′2—CO—NRA′3—, —NRA′2—SO2— or —SO2—NRA′2—;
• RA′1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl, provided that when XA′ is a single bond, RA′1 is not a hydrogen atom;
• RA′2 and RA′3 are each independently, a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl;
• XA′ is —NRA′2—, —CO—NRA′2—, —CO—O—NRA′2—, —O—CO—NRA′2— or —SO2—NRA′2—;
• RA′1 and RA′2 may be taken together with an adjacent nitrogen atom to form substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• when XA′ is —NRA′2—CO—NRA′3—, RA′1 and RA′3 may be taken together with an adjacent nitrogen atom to form substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl.

6:

• The compound according to claim 1 or its pharmaceutically acceptable salt, wherein ring A is any one of the following rings:
• wherein
• ring B, ring C and ring D are each independently monocyclic aromatic carbocycle, monocyclic non-aromatic carbocycle, monocyclic aromatic heterocycle or monocyclic non-aromatic heterocycle;
• wherein the ring may form a spiro ring together with another aromatic carbocycle, non-aromatic carbocycle, aromatic heterocycle or non-aromatic heterocycle;
• and/or two atoms constituting each ring which is not adjacent to each other may be cross-linked with alkylene, alkenylene or alkynylene;
• RB is each independently, halogen, cyano, nitro, oxo, azide, trimethylsilyl or —XB—RB1;
• XB is a single bond, —O—, —S—, —NRB2—, ═N—, —CO—, —SO2—, —O—CO—, —CO—O—, —NRB2—CO—, —CO—NRB2—, —NRB2—CO—O—, —CO—O—NRB2—, —O—CO—NRB2—, —NRB—O—CO—, —CO—NRB2—O—, —O—NRB2—CO—, —NRB2—CO—NRB3—, —NRB2—SO2— or —SO2—NRB2—;
• RB1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl, provided that when XB is a single bond, RB1 is not a hydrogen atom;
• RB2 and RB3 are each independently a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl;
• when XB is —NRB2—, —CO—NRB2—, —CO—O—NRB2—, —O—CO—NRB2— or —SO2—NRB2—, RB1 and RB2 may be taken together with an adjacent nitrogen atom to form substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• when XB is —NRB2—CO—NRB3—, RB1 and RB3 may be taken together with an adjacent nitrogen atom to form substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• p is any integer of 0 to 12;
• R1 and RB may be taken together with an adjacent atom to form aromatic carbocycle, non-aromatic carbocycle, aromatic heterocycle or non-aromatic heterocycle, wherein the ring may be substituted with one or more of the same or different RB′;
• RB′ is each independently, halogen, cyano, nitro, oxo, azide, trimethylsilyl or —XB′—RB′1;
• wherein XB′ is a single bond, —O—, —S—, —NRB2—, ═N—, —CO—, —SO2—, —O—CO—, —CO—O—, —NRB′2—CO—, —CO—NRB′2—, —NRB′2—CO—O—, —CO—O—NRB2—, —O—CO—NRB′2—, —NRB′2—O—CO—, —CO—NRB′2—O—, —O—NRB2—CO—, —NRB′2—CO—NRB′3—, —NRB′2—SO2— or —SO2—NRB′2—;
• RB′1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl, provided that when XB′ is a single bond, RB′1 is not a hydrogen atom;
• RB′2 and RB′3 are each independently, a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl;
• when XB′ is —NRB′2—, —CO—NRB′2—, —CO—O—NRB′2—, —O—CO—NRB′2— or —SO2—NRB′2—, RB′1 and RB′2 may be taken together with an adjacent nitrogen atom to form substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• when XB′ is —NRB′2—CO—NRB′3—, RB′1 and RB′3 may be taken together with an adjacent nitrogen atom to form substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• s is any integer of 0 to 12;
• RC is each independently, halogen, cyano, nitro, oxo, azide, trimethylsilyl or —XC—RC1;
• XC is a single bond, —O—, —S—, —NRC2—, ═N—, —CO—, —SO2—, —O—CO—, —CO—O—, —NRC2—CO—, —CO—NRC2—, —NRC2—CO—O—, —CO—O—NRC2—, —O—CO—NRC2—, —NR2—O—CO—, —CO—NRC2—O—, —O—NRC2—CO—, —NRC2—CO—NRC3—, —NRC2—SO2— or —SO2—NRC2—;
• RC1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl, provided that when XC is a single bond, RC1 is not a hydrogen atom;
• RC2 and RC3 are each independently, a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl;
• when XC is —NRC2—, —CO—NRC2—, —CO—O—NRC2—, —O—CO—NRC2— or —SO2—NRC2—, RC1 and RC2 may be taken together with an adjacent nitrogen atom to form substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• when XC is —NRC2—CO—NRC3—, RC1 and RC3 may be taken together with an adjacent nitrogen atom to form substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• q is any integer of 0 to 12;
• RB and RC may be taken together with an adjacent atom to form aromatic carbocycle, non-aromatic carbocycle, aromatic heterocycle or non-aromatic heterocycle, wherein the ring may be substituted with one or more of the same or different RB;
• and
• RD is each independently, halogen, cyano, nitro, oxo, azide, trimethylsilyl or —XD—RD1;
• XD is a single bond, —O—, —S—, —NRD2—, ═N—, —CO—, —SO2—, —O—CO—, —CO—O—, —NRD2—CO—, —CO—NRD2—, —NRD2—CO—O—, —CO—O—NRD2—, —O—CO—NRD2—, —NRD2—O—CO—, —CO—NRD2—O—, —O—NRD2—CO—, —NRD2—CO—NRD3—, —NRD2—SO2— or —SO2—NRD2—;
• RD1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl or substituted or unsubstituted non-aromatic heterocyclyl, provided that when XD is a single bond, RD is not a hydrogen atom;
• RD2 and RD3 are each independently, a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl;
• when XD is —NRD2—, —CO—NRD2—, —CO—O—NRD2—, —O—CO—NRD2— or —SO2—NRD2—, RD1 and RD2 may be taken together with an adjacent nitrogen atom to form substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl,
• when XD is —NRD2—CO—NRD3—, RD1 and RD3 may be taken together with an adjacent nitrogen atom to form substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• r is any integer 0 to 12;
• RC and RD may be taken together with an adjacent atom to form aromatic carbocycle, non-aromatic carbocycle, aromatic heterocycle or non-aromatic heterocycle, wherein the ring may be substituted with one or more of the same or different RC.

15:

• The compound according to claim 1 represented by the following formula:
• or its pharmaceutically acceptable salt,
• wherein
• ring A is substituted or unsubstituted heterocycle;
• R1 is alkyl;
• or R1 may be taken together with atom(s) constituting the ring A to form substituted or unsubstituted heterocycle;
• R2 is alkyloxy, or substituted or unsubstituted cycloalkyloxy;
• R3 is substituted or unsubstituted phenyl which may be fused, or substituted or unsubstituted 5- to 8-membered heterocyclyl which may be fused;
• R6 is alkyl.

16:

• The compound according to claim 1 represented by any one of following formulas:
• or its pharmaceutically acceptable salt,
• wherein
• ring C and ring D are each independently benzene or 5- to 8-membered heterocycle;
• ring B′ is 5- to 8-membered heterocycle;
• ring E is optionally cross-linked 5- to 8-membered carbocycle;
• RB″ and RB′″ are each independently a hydrogen atom, alkyl, cycloalkyl, cycloalkylalkyl, formyl, alkoxycarbonyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkylaralkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyclylalkyl, or substituted sulfonyl;
• a broken line means the presence or absence of bond;
• k and m are each independently an integer of 0 to 4;
• R1 is alkyl;
• R2 is alkyloxy, or substituted or unsubstituted cycloalkyloxy;
• R3 is substituted or unsubstituted phenyl which may be fused, or substituted or unsubstituted 5- to 8-membered heterocyclyl which may be fused;
• R6 is alkyl;
• RE is the same meaning as RC;
• t is any integer of 0 to 12;
• RB is each independently, halogen, cyano, nitro, oxo, azide, trimethylsilyl or —XB—RB1;
• XB is a single bond, —O—, —S—, —NRB2—, ═N—, —CO—, —SO2—, —O—CO—, —CO—O—, —NRB2—CO—, —CO—NRB2—, —NRB2—CO—O—, —CO—O—NRB2—, —O—CO—NRB2—, —NRB2—O—CO—, —CO—NRB2—O—, —O—NRB2—CO—, —NRB2—CO—NRB3—, —NRB2—SO2— or —SO2—NRB2—;
• RB1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl, provided that when XB is a single bond, RB1 is not a hydrogen atom;
• RB2 and RB3 are each independently a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl;
• when XB is —NRB2—, —CO—NRB2—, —CO—O—NRB2—, —O—CO—NRB2— or —SO2—NRB2—, RB1 and RB2 may be taken together with an adjacent nitrogen atom to form substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• when XB is —NRB2—CO—NRB3—, RB1 and RB3 may be taken together with an adjacent nitrogen atom to form substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• q is any integer of 0 to 12;
• and
• s is any integer of 0 to 12.