Agents and compositions for eliciting an immune response
AssigneeCancure Limited
InventorStephen RALPH
Life of this patent
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Abstract
Immune-potentiating compositions include cells exhibiting enhanced antigen-presenting functions. The compositions are generally useful in facilitating the stimulation of host immune cell responses, including selective and targeted immune cell responses, and are particularly useful in the treatment and/or prophylaxis of cancers, tumors and pathogenic infections.
Claims31
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A composition comprising a B7 molecule, a 4-1BB agonist and animal cancer or tumor cells contacted with at least one exogenous IFN for a time and under conditions sufficient to enhance the antigen presenting function of the cells.
A method for enhancing an immune response to a target cancer or tumor antigen in a subject, the method comprising administering to the subject an effective amount of a composition comprising a B7 molecule, a 4-1BB agonist and animal cancer or tumor cells contacted with at least one exogenous IFN for a time and under conditions sufficient to enhance the antigen presenting function of the cells.
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Dependencies are inferred from the claim text.