hTERT MODULATORS AND METHODS OF USE

A compound of the formula:

• wherein
• X is O or N such that when X is O, bond a is absent and when X is N, bond a is present;
• n is 0 or 1 such that:when n=0, R3 is —NHC(═NH)NH2;
• andwhen n=1, R3 is hydrogen, alkyl, cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted heteroaryl or optionally substituted aryl, wherein each substituent is independently selected from the group consisting of halogen, cyano, nitro, azido, haloalkyl, cycloalkyl, heteroaryl, aryl, —NR7R8, —NR7C(O)R8, —C(O)NR7R8, —C(O)R9, —C(O)OR9, —S(O)R9, —SO2R9, —SO2NR7R8, —OR9 and —SR9;
• R1 is optionally substituted aryl or optionally substituted heteroaryl, wherein each substituent is independently selected from the group consisting of halogen, cyano, nitro, azido, haloalkyl, cycloalkyl, —NR4R5, —NR4C(O)R5, —C(O)NR4R5, —C(O)R6,—C(O)OR6, —S(O)R6, —SO2R6, —SO2NR4R5, —OR6, and —SR6;
• R2 is selected from the group consisting of hydrogen, halogen, alkyl, haloalkyl and cycloalkyl;
• each of R4 and R5 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, heteroaryl, aryl and cycloalkyl, or R4 and R5 together with the nitrogen atom to which they are attached to form an optionally substituted monocyclic or bicyclic ring with one or more heteroatoms;
• R6 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, heteraryl, aryl, cycloalkyl, wherein the alkyl, alkenyl, heteraryl, aryl and cycloalkyl are optionally substituted with one or more halo, cyano, alkylamino, alkoxy, aryl, heteroaryl or heterocyclyl groups;
• each of R7 and R8 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, heteroaryl, aryl and cycloalkyl, or R7 and R8 together with the nitrogen group to which they are attached to form an optionally substituted monocyclic or bicyclic ring with one or more heteroatoms;
• R9 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, heteraryl, aryl cycloalkyl, wherein the alkyl, alkenyl, heteraryl, aryl and cycloalkyl are optionally substituted with one or more halo, cyano, alkylamino, alkoxy, aryl, heteroaryl or heterocyclyl groups;
• eachR11 and R12 is independently —H, —COR13 or —CH3;
• and
• R13 is alkyl, haloalkyl, alkenyl, alkynyl, or cycloalkyl