Liquid chromatography columns with structured walls
AssigneeAgilent Technologies, Inc.
InventorsHongfeng Yin, Reid A. Brennen, Eric Lyster, Roger Slocum
Life of this patent
Estimating the term…
Abstract
A liquid chromatography (LC) column includes a wall having a length along a central axis from the inlet end to the outlet end, the wall enclosing a column interior and having a column radius relative to the central axis, the wall comprising a structured portion configured such that the column radius varies along the length; and a plurality of particles packed in the column interior, wherein at least some of the particles are in contact with the structured portion.
Claims20
A liquid chromatography (LC) column, comprising:
- an inlet end;
- an outlet end;
- a wall having a length along a central axis of the column from the inlet end to the outlet end, the wall enclosing a column interior and comprising a main portion and a structured portion, the structured portion comprising a pattern of features spaced from each other,
- wherein the main portion is positioned at a radius from the central axis, and the features are positioned at one or more radii from the central axis different from the radius of the main portion;
- and
- a plurality of particles packed in the column interior, wherein at least some of the particles are in contact with the structured portion.
A method for fabricating a liquid chromatography (LC) column, the method comprising:
- forming a wall comprising an inlet end, an outlet end, and a length along a central axis from the inlet end to the outlet end, wherein the wall encloses a column interior and comprises a main portion;
- forming a structured portion on the wall facing the column interior, the structured portion comprising a pattern of features spaced from each other,
- wherein the main portion is positioned at a radius from the central axis, and the features are positioned at one or more radii from the central axis different from the radius of the main portion;
- and
- after forming the structured portion, forming a packing of particles in the column interior, wherein at least some of the particles are in contact with the structured portion.
Dependencies are inferred from the claim text.