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US 2018/0339048 A1Published application
Therapeutic and Diagnostic Probes
AssigneeLI-COR, Inc.
InventorsDavid L. Dilley, Joy Kovar
Life of this patent
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Abstract
The present invention provides compositions and methods of use of nanoparticle-based probes for in vivo imaging and therapy. The probes can be used to track diseased target cells by non-invasive imaging in the near-infrared range. Additionally, the probes can induce cell death of the target cells via photodynamic treatment.
Claims15
A probe comprising a nanocarrier attached to both (1) an imaging agent and (2) a therapeutic agent, which is IRDYE700DX.
A method for detecting a target cell in an individual, said method comprising:
- (a) contacting said target cell with a probe comprising a nanocarrier attached to both (1) an imaging agent and (2) a therapeutic agent, which is IRDYE700DX, wherein the probe selectively associates with the said target cell;
- and
- (b) detecting said imaging agent thereby providing an indication of the presence and/or location of said target cell in the individual.
A method for inducing cell death in a target cell in an individual, said method comprising:
- (a) contacting said target cell with a probe comprising a nanocarrier attached to both (1) an imaging agent and (2) a therapeutic agent, which is IRDYE700DX, wherein the probe selectively associates with said target cell;
- and
- (b) exposing said therapeutic agent to a photoactivating light, thereby inducing apoptosis and/or necrosis of said target cell in the individual.
Dependencies are inferred from the claim text.