Target modification for tracking and detection
AssigneeTwo Pore Guys, Inc.
InventorsTrevor J. Morin, Daniel A. Heller, William B. Dunbar, Tyler Shropshire
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Abstract
The present invention is directed to a target molecule modified to facilitate detection in a nanopore deice. The present invention further relates to a method of detecting such a modified target molecule using a nanopore device. It also disclose a method of using such a modified target molecule for tracking and verification of pharmaceutical, chemical or biological products and for measuring various conditions of a sample comprising the modified target molecule.
Claims71
A complex designed for nanopore detection, comprising:
- a target molecule comprising a first attachment site;
- and
- a driver molecule comprising a first attachment site,
- wherein the first attachment site of the driver molecule makes a covalent bond to the first attachment site of the target molecule.
A complex designed for nanopore detection, comprising:
- a target molecule comprising a first attachment site;
- and
- a linker molecule comprising a first attachment site and a second attachment site,
- wherein the first attachment site of the linker molecule makes a covalent bond to the first attachment site of the target molecule, and
- the second attachment site of the linker molecule is a binding site for a driver molecule.
A modified target molecule designed for nanopore detection, comprising
- a first attachment site for a driver molecule or a linker molecule, wherein the attachment site is generated by a first modification of a target molecule.
Dependencies are inferred from the claim text.