Pharmaceutical compositions for prevention or treatment of neurodegenerative diseases
AssigneesInserm (Institut National De La Sante Et De La Recherche Medicale), Universite Paul Sabatier Toulouse III, Centre National de la Recherche Scientifique (CNRS), Universite Pierre Et Marie Curie (Paris 6), Icm (Institut Du Cerveau Et De La Moelle éPinièRe)
InventorsDaniel DUNIA, Marion SZELECHOWSKI, Alexandre BETOURNE, Stephane HUNOT
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Abstract
The present invention relates to methods and compositions for the prevention or treatment of neurodegenerative diseases.
Claims4
1-8. (canceled)
A method for preventing or treating i) neurodegenerative disease, ii) neurodegenerative complications in a subject suffering from ischemia damage, or iii) mitochondrial disease in a subject in need thereof comprising
- I) a polypeptide comprising
- i) an amino acid sequence ranging from glycine at position 59 to alanine at position 85 in an amino acid sequence SEQ ID NO:1 or,
- ii) an amino acid sequence having at least 70% identity with the amino acid sequence ranging from glycine at position 59 to alanine at position 85 in the amino acid sequence SEQ ID NO:1,
- wherein the polypeptide is not the amino acid sequence SEQ ID NO:
- 1:
- II) a fusion protein comprising the polypeptide;
- III) a nucleic acid sequence encoding the polypeptide or the fusion protein;
- IV) a vector comprising the nucleic acid sequence;
- or
- V) a pharmaceutical composition comprising the polypeptide or fusion protein and a pharmaceutically acceptable carrier.
11-13. (canceled)
Dependencies are inferred from the claim text.