Mtor inhibitors and methods of use thereof

A compound of Formula (I) or a pharmaceutically acceptable salt thereof:

• wherein:
• Y1 and Y2 are independently NH, O, or S;
• L1 and L2 are independently C2-C8 alkylene or C2-C8 alkenylene;
• Rx is, independently for each occurrence, C3-C6 branched alkyl;
• Ry is alkyl, aralkyl, cycloalkyl, or cycloalkylalkyl;
• Rz is nitro or arylsulfonyl;
• Z1 is —H, NH2,
• Z2 is
• n is 1, 2, or 3:
• m is 1, 2, or 3.