Compositions and methods for improving heart function and treating heart failure
OwnerBenjamin L. Prosser, Kenneth B. Marguliesinventors
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Abstract
Described herein is a method for improving or stabilizing cardiac function by inhibiting tubulin carboxypeptidase (TCP). Also described herein is a method for treating heart failure in humans comprising dosing a patient with a therapeutic which interferes with detyrosinated microtubules in cardiomyocytes. Also provided are viral vectors which comprise a nucleic acid encoding a tubulin tyrosine ligase (TTL) gene under the control of regulatory elements direct expression thereof. Compositions are also provided which contain such viral vectors formulated for delivery to a human patient.
Claims18
A method for improving heart function in humans comprising treating a patient with a therapeutic which inhibits tubulin carboxypeptidase (TCP).
A method for treating heart failure in humans comprising dosing a patient with a therapeutic which interferes with detyrosinated microtubules in cardiomyocytes.
A method for improving heart function in humans comprising delivering a composition comprising a therapeutic which increases cardiac microtubule tyrosination,
A replication-defective vector comprising a tubulin tyrosine ligase (TTL) under the control of a regulatory control sequence which directs expression thereof in the heart.
Dependencies are inferred from the claim text.